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Monolithic stationary
phases for high speed separations
Stationary phases for
separations involving liquid mobile phases have traditionally comprised
small, porous particles that are packed into a suitable column. Recent research internationally has shown that very high
performance stationary phases (both polymeric and silica-based) can be
formed from continuous blocks of polymerised material, provided these
have a suitable pore structure. Such
materials are termed "monolithic" and are very attractive
because of their low-pressure resistance to liquid flow, their extremely
high chromatographic efficiency, and their suitability for very fast
separations. Again, new
developments from Australia (for example at the University of Tasmania)
have been submitted for patent approval and strong commercialisation
possibilities exist.
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